Category Archives: Research

Comparison of single- versus seven-day Holter analysis for the identification of dilated cardiomyopathy predictive criteria in apparently healthy Doberman Pinscher dogs

Comparison of single- versus seven-day Holter analysis for the identification of dilated cardiomyopathy predictive criteria in apparently healthy Doberman Pinscher dogs T. Gunasekaran, BVSc & AH, N.B. Olivier, PhD, R.A. Sanders, MS Received 12 March 2019; received in revised form 13 January 2020; accepted 22 January 2020 Abstract Introduction: The primary objective of this study… Read More »

European Society of Veterinary Cardiology screening guidelines for dilated cardiomyopathy in Doberman Pinschers

European Society of Veterinary Cardiology screening guidelines for dilated cardiomyopathy in Doberman Pinschers G. Wess, DVM, Dr. habil. DACVIM-CA, DECVIM-IM, DECVIM-CA a,*, O. Domenech, DVM, MSc, DECVIM-CA b, J. Dukes-McEwan, BVMS, MVM, PhD, DVC, DECVIM-CA (Cardiology) MRCVS c, J. Häggström, DVM, PhD. DECVIM-CA d, S. Gordon, DVM, DVSc, DACVIM-CA Received 22 March 2017; received in… Read More »

A missense variant in the titin gene in Doberman pinscher dogs with familial dilated cardiomyopathy and sudden cardiac death

Kathryn M. Meurs1  · Steven G. Friedenberg2 · Justin Kolb5 · Chandra Saripalli5 · Paola Tonino5 · Kathleen Woodruff1 · Natasha J. Olby1 · Bruce W. Keene1 · Darcy B. Adin1 · Oriana L. Yost1 · Teresa C. DeFrancesco1 · Sunshine Lahmers3 · Sandra Tou1 · G. Diane Shelton4 · Henk Granzier5 Received: 12 August 2018 / Accepted: 4 January 2019 © Springer-Verlag GmbH Germany, part of Springer Nature 2019 Abstract The dog provides a large animal model of familial dilated cardiomyopathy for the study of important aspects of this common… Read More »

Doberman pinschers present autoimmunity associated with functional autoantibodies: A model to study the autoimmune background of human dilated cardiomyopathy

PLoS One. 2019; 14(7): e0214263. Published online 2019 Jul 5. doi: 10.1371/journal.pone.0214263 Gerhard Wess, Conceptualization, Project administration, Supervision,1 Gerd Wallukat, Formal analysis, Investigation, Methodology,2 Anna Fritscher, Investigation, Methodology,1 Niels-Peter Becker, Investigation, Writing – original draft,2 Katrin Wenzel, Investigation, Methodology,2 Johannes Müller, Conceptualization, Project administration, Supervision,2 and Ingolf Schimke, Conceptualization, Formal analysis, Project administration, Supervision, Writing… Read More »

Genomic Analyses Reveal the Influence of Geographic Origin, Migration and Hybridization on Modern Dog Breed Development

Genomic Analyses Reveal the Influence of Geographic Origin, Migration and Hybridization on Modern Dog Breed Development by Heidi G. Parker – Dayna L. Dreger – Maud Rimbault – Brian W. Davis – Alexandra B. Mullen – Gretchen Carpintero-Ramirez – Elaine A. Ostrander Highlights: – Neighbor joining cladogram of 161 breeds establishes 23 supported clades –… Read More »

DOG STAR RISING: THE CANINE GENETIC SYSTEM

THE CANINE GENETIC SYSTEM by Nathan B. Sutter and Elaine A. Ostrander Abstract: Purebred dogs are providing invaluable information about morphology, behaviour and complex diseases, both of themselves and humans, by supplying tractable populations in which to map genes that control those processes. The diversification of dog breeds has led to the development of breeds… Read More »

DO LARGE DOGS DIE YOUNG?

DO LARGE DOGS DIE YOUNG? Size and longevity in dogs by Frietson Galis1, Inke van der Sluijs1, Tom J. M. Van Dooren1, Johan A. J. Metz1,2, Marc Nussbaumer Abstract: In most animal taxa longevity increases with body size across species, as predicted by the oxidative stress theory of aging. Contrastingly, in within-species comparisons of mammals… Read More »

Single-Nucleotide-Polymorphism – by Professor Paul Jones

Single-Nucleotide-Polymorphism Based Association Mapping of Dog Stereotypes by Paul Jones – Kevin Chase – Alan Martin – Pluis Davern – Elaine A. Ostrander – Karl G. Lark ABSTRACT Phenotypic stereotypes are traits, often polygenic, that have been stringently selected to conform to specific criteria. In dogs, Canis familiaris, stereotypes result from breed standards set for… Read More »