Category Archives: Research

A missense variant in the titin gene in Doberman pinscher dogs with familial dilated cardiomyopathy and sudden cardiac death

Kathryn M. Meurs1  · Steven G. Friedenberg2 · Justin Kolb5 · Chandra Saripalli5 · Paola Tonino5 · Kathleen Woodruff1 · Natasha J. Olby1 · Bruce W. Keene1 · Darcy B. Adin1 · Oriana L. Yost1 · Teresa C. DeFrancesco1 · Sunshine Lahmers3 · Sandra Tou1 · G. Diane Shelton4 · Henk Granzier5 Received: 12 August 2018 / Accepted: 4 January 2019 © Springer-Verlag GmbH Germany, part of Springer Nature 2019 Abstract The dog provides a large animal model of familial dilated cardiomyopathy for the study of important aspects of this common… Read More »

Doberman pinschers present autoimmunity associated with functional autoantibodies: A model to study the autoimmune background of human dilated cardiomyopathy

PLoS One. 2019; 14(7): e0214263. Published online 2019 Jul 5. doi: 10.1371/journal.pone.0214263 Gerhard Wess, Conceptualization, Project administration, Supervision,1 Gerd Wallukat, Formal analysis, Investigation, Methodology,2 Anna Fritscher, Investigation, Methodology,1 Niels-Peter Becker, Investigation, Writing – original draft,2 Katrin Wenzel, Investigation, Methodology,2 Johannes Müller, Conceptualization, Project administration, Supervision,2 and Ingolf Schimke, Conceptualization, Formal analysis, Project administration, Supervision, Writing… Read More »

Genomic Analyses Reveal the Influence of Geographic Origin, Migration and Hybridization on Modern Dog Breed Development

Genomic Analyses Reveal the Influence of Geographic Origin, Migration and Hybridization on Modern Dog Breed Development by Heidi G. Parker – Dayna L. Dreger – Maud Rimbault – Brian W. Davis – Alexandra B. Mullen – Gretchen Carpintero-Ramirez – Elaine A. Ostrander Highlights: – Neighbor joining cladogram of 161 breeds establishes 23 supported clades –… Read More »

DOG STAR RISING: THE CANINE GENETIC SYSTEM

THE CANINE GENETIC SYSTEM by Nathan B. Sutter and Elaine A. Ostrander Abstract: Purebred dogs are providing invaluable information about morphology, behaviour and complex diseases, both of themselves and humans, by supplying tractable populations in which to map genes that control those processes. The diversification of dog breeds has led to the development of breeds… Read More »

DO LARGE DOGS DIE YOUNG?

DO LARGE DOGS DIE YOUNG? Size and longevity in dogs by Frietson Galis1, Inke van der Sluijs1, Tom J. M. Van Dooren1, Johan A. J. Metz1,2, Marc Nussbaumer Abstract: In most animal taxa longevity increases with body size across species, as predicted by the oxidative stress theory of aging. Contrastingly, in within-species comparisons of mammals… Read More »

Single-Nucleotide-Polymorphism – by Professor Paul Jones

Single-Nucleotide-Polymorphism Based Association Mapping of Dog Stereotypes by Paul Jones – Kevin Chase – Alan Martin – Pluis Davern – Elaine A. Ostrander – Karl G. Lark ABSTRACT Phenotypic stereotypes are traits, often polygenic, that have been stringently selected to conform to specific criteria. In dogs, Canis familiaris, stereotypes result from breed standards set for… Read More »

Genetic diversity of dog breeds – by Professor G. Leroy

Genetic diversity of dog breeds – between-breed diversity, breed assignation and conservation approaches – by G. Leroy – E. Verrier – J. C. Meriaux – X. Rognon Summary Genetic relationships between 61 dog breeds were investigated, using a sampling of 1514 animals and a panel of 21 microsatellite markers. Based on the results from distance-based… Read More »

Diagnostische Parameter für die dilatative Kardiomyopathie beim Dobermann – von Judith Mäurer (2010)

Diagnostische Parameter für die dilatative Kardiomyopathie beim Dobermann von Judith Mäurer (2010) EINLEITUNG Die dilatative Kardiomyopathie ist mit Prävalenzen bis zu 62 % die häufigste Herzerkrankung beim Dobermann. Es handelt sich um eine Erkrankung mit einem autosomal dominanten Erbgang, von der hauptsächlich ältere Dobermänner betroffen sind. Der Verlauf der Krankheit, der durch eine okkulte Phase… Read More »

INVASIVE HEMODYNAMIC MONITORING: PHYSIOLOGICAL PRINCIPLES AND CLINICAL APPLICATIONS – by Jan M. Headley

INVASIVE HEMODYNAMIC MONITORING: PHYSIOLOGICAL PRINCIPLES AND CLINICAL APPLICATIONS by Jan M. Headley, RN, BS, CCRN Irvine, California INTRODUCTION During the last 25 years, the art of critical care medicine has greatly changed. This process has been due in part to the formation of specialized units for patient care, advances in technology, and a better understanding… Read More »